Aberrant epigenetic landscape were widely found in many kinds of cancer. Different histone modification and DNA methylation alteration in cancer usually related gene expression dysregulation, and change global chromatin structure. By using methylated DNA immunoprecipitation followed by sequencing(MeDIP) and methylation-sensitive restriction enzyme sequencing (MRE-seq), we described complete DNA methylation of cancer. Combined with histone ChIP-seq, we depict genome-wide epigenetic alteration in cancer.